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Clinical Features of Pregnant Women with Thalassemia in Non Endemic Area / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 2022-2027, 2020.
Artigo em Chinês | WPRIM | ID: wpr-880009
ABSTRACT
OBJECTIVE@#To investigate the clinical features of pregnant women with thalassemia in non endemic area, and to prevent the births of babies with intermedia or major thalassemia.@*METHODS@#Two hundred and thirty-five pregnants women with thalassemia diagnosed from March 2015 to April 2016 in our hospital were enrolled and retrospectively analysed. The blood routine and hemoglobin electrophoresis were performed respectively by XN-9000 automatic blood cell analyzer and HYDRASYS hemoglobin electrophoresis apparatus. The three commonest deletion of α-thalassemia, the three non-deletion α-thalassemia and 21 known β-thalassemia mutation were all detected by fluorescence melting curve analysis.@*RESULTS@#Among 235 pregnant women of thalassemia, the majority were β-thalassemia, which were followed by α-thalassemia and composite thalassemia. Most pregnant women showed a mild anemia, and suffered from microcytic anemia, but less suffered from iron deficiency anemia. The ratio of second-child pregnant women was increased, and the ratio was close to one third both in α-thalassemia and β-thalassemia patients, and 75% patients were composite thalassemia. HbF was found to be more in native pregnant women with β-thalassemia. Hemoglobin isomer was easy to found in the pregnant with α-thalassemia, and they were all non native. The genotype of --@*CONCLUSION@#More pregnant women with thalassemia are founded to be in non endemic area, and shows their own unique clinical features. It is certainly to detect thalassemia mutation in their spouse and their babies, to prevent the births of babies with intermedia or major thalassemia.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estudos Retrospectivos / Talassemia beta / Talassemia alfa / Gestantes / Genótipo / Mutação Tipo de estudo: Estudo observacional Limite: Criança / Feminino / Humanos / Lactente / Gravidez Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Estudos Retrospectivos / Talassemia beta / Talassemia alfa / Gestantes / Genótipo / Mutação Tipo de estudo: Estudo observacional Limite: Criança / Feminino / Humanos / Lactente / Gravidez Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2020 Tipo de documento: Artigo