Molecular mechanisms of general anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 3-8, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-88005
ABSTRACT
General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood. Moreover, the general anesthetic state comprises multiple components (amnesia, unconsciousness, analgesia, and immobility), each of which is mediated by different receptors and neuronal pathways. Recently, neurotransmitter- and voltage-gated ion channels have emerged as the most likely molecular targets for general anesthetics. The gamma-aminobutyric acid type A (GABA(A)) receptors are leading candidates as a primary target of general anesthetics. This review summarizes current knowledge on how anesthetics modify GABA(A) receptor function.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Inconsciência
/
Sistema Nervoso Central
/
Receptores de GABA-A
/
Transmissão Sináptica
/
Anestésicos Gerais
/
Ácido gama-Aminobutírico
/
Analgesia
/
Canais Iônicos
/
Anestesia Geral
/
Anestésicos
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS