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Expression and Significance of Low-Density Lipoprotein-Related Receptors 5 and 6 in the Wnt/β-Catenin Signaling Pathway in Childhood Acute Lymphoblastic Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 433-438, 2021.
Artigo em Chinês | WPRIM | ID: wpr-880093
ABSTRACT
OBJECTIVE@#To investigate the significance of low-density lipoprotein receptor-related protein 5 and 6 (LRP5/6) in the Wnt/β-catenin signaling pathway in the pathogenesis and prognosis of childhood acute lymphoblastic leukemia (ALL).@*METHODS@#A total of 43 children who were newly diagnosed and achieved complete remission after remission induction therapy were enrolled. The children before treatment were included in incipient group, and after treatment when achieved complete remission included in remission group. A total of 39 children with immune thrombocytopenia were enrolled in control group. Three milliliter bone marrow samples were collected from above-mentioned each group. QRT-PCR was used to determine the mRNA expression of LRP5 and LRP6 in blood mononuclear cells of bone marrow. Western blot was used to detect the protein expression of LRP5 and LRP6. According to the protein expression levels of LRP5 and LRP6, the children were divided into low-expression group and high-expression group, and the clinical biological characteristics were compared between these two groups. Survival analysis was performed by Kaplan-Meier method.@*RESULTS@#Both mRNA and protein expression levels of LRP5 and 6 were upregulated in the incipient group compared with the control and remission group (P<0.05). The mRNA and protein expressions of LRP5 and LRP6 in the high-risk group were higher than those in the medium-risk group (P<0.05), it is the same as in the medium-risk group than the low-risk group (P<0.05). The mRNA and protein expressions of LRP5 and 6 positively correlated with risk degree in the incipient group (r@*CONCLUSION@#The high expression of LRP5/6 may be one of the pathogenesis of childhood ALL, and the degree of LRP5/6 increase may be related to the risk level.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Receptores de LDL / Beta Catenina / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Via de Sinalização Wnt / Lipoproteínas LDL Tipo de estudo: Estudo prognóstico Limite: Criança / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Receptores de LDL / Beta Catenina / Leucemia-Linfoma Linfoblástico de Células Precursoras / Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Via de Sinalização Wnt / Lipoproteínas LDL Tipo de estudo: Estudo prognóstico Limite: Criança / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2021 Tipo de documento: Artigo