Mechanism of the Notch signaling pathway in enhancing the efficacy of chemotherapy drugs in osteosarcoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1234-1240, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-880591
ABSTRACT
Osteosarcoma is the most common malignant tumors of bone. Since 1970s, researchers had used chemotherapy drugs to treat osteosarcoma. However, multidrug resistance is a major adverse reaction that affects the efficacy of chemotherapy drugs, leading to the reduced survival rate of osteosarcoma patients. The Notch signaling pathway plays an important role in osteosarcoma proliferation, which affects tumor resistance by reducing intracellular drug accumulation, regulating epithelial-mesenchymal transition, dysregulating microRNA, disrupting the expression of apoptosis genes, and regulating tumor stem cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ósseas
/
Preparações Farmacêuticas
/
Transdução de Sinais
/
Osteossarcoma
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Receptores Notch
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2020
Tipo de documento:
Artigo
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