Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1399-1405, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-880776
ABSTRACT
OBJECTIVE@#To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.@*METHODS@#Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the @*RESULTS@#In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (@*CONCLUSIONS@#Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenantrenos
/
Ratos Sprague-Dawley
/
Diterpenos
/
Compostos de Epóxi
/
Furanos
/
Glucosídeos
/
Rim
/
Anti-Inflamatórios
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2020
Tipo de documento:
Artigo
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