SBi4211 alleviates gp120-induced central nervous system injury / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1693-1702, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-880820
ABSTRACT
OBJECTIVE@#To explore the protective effect of SBi4211 (heptamidine), an inhibitor of S100B, against central nervous system injury induced by HIV-1 envelope protein gp120.@*METHODS@#In an @*RESULTS@#In the cell co-culture system, SBi4211 treatment significantly inhibited gp120-induced expression of S100B, RAGE and GFAP in U251 cells (@*CONCLUSIONS@#SBi4211 can protect neurons from gp120-induced neurotoxicity possibly by inhibiting the S100B/ RAGE-mediated signaling pathway.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
Proteína gp120 do Envelope de HIV
/
Sistema Nervoso Central
/
Western Blotting
/
Astrócitos
/
Subunidade beta da Proteína Ligante de Cálcio S100
/
Neurônios
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2020
Tipo de documento:
Artigo
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