Pathogenic role of NDUFA13 inactivation in spontaneous hepatitis in mice and the mechanism / 南方医科大学学报
Journal of Southern Medical University
;
(12): 55-63, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-880827
ABSTRACT
OBJECTIVE@#To investigate the role of NDUFA13 inactivation in the pathogenesis of spontaneous hepatitis in mice and explore the possible mechanisms.@*METHODS@#Hepatocyte-specific NDUFA13 knockout (NDUFA13@*RESULTS@#Liver-specific NDUFA13 heterozygous knockout mice were successfully constructed as verified by PCR results. HE staining revealed severe liver damage in both 4- week-old and 2-year-old NDUFA13@*CONCLUSIONS@#Hepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-κB/NLRP3 signaling.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
NF-kappa B
/
Inflamassomos
/
Proteína 3 que Contém Domínio de Pirina da Família NLR
/
Hepatite
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2021
Tipo de documento:
Artigo
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