Establishment of a mouse model bearing orthotopic temozolomide-resistant glioma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 69-74, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-880829
ABSTRACT
OBJECTIVE@#To establish a mouse model bearing orthotopic temozolomide (TMZ)-resistant glioma that mimics the development of drug resistance in gliomas @*METHODS@#Seventy-eight adult C57BL/6 mice were randomly divided into 6 groups (@*RESULTS@#The mouse models bearing TMZresistant glioma was successfully established. The cells from the high-dose induced group showed a significantly higher colony-forming rate than those from the high-dose control group (@*CONCLUSIONS@#Progressive increase of TMZ doses in mice bearing orthotopic gliomas can effectively induce TMZ resistance of the gliomas.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Encefálicas
/
Resistencia a Medicamentos Antineoplásicos
/
Antineoplásicos Alquilantes
/
Linhagem Celular Tumoral
/
Modelos Animais de Doenças
/
Temozolomida
/
Glioma
/
Camundongos Endogâmicos C57BL
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2021
Tipo de documento:
Artigo
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