Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Protein & Cell
;
(12): 825-845, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-880875
ABSTRACT
This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed a significant correlation between ERK5 activity and FAK expression and its phosphorylation at the Ser
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Movimento Celular
/
Sistema de Sinalização das MAP Quinases
/
Proteína Quinase 7 Ativada por Mitógeno
/
Quinase 1 de Adesão Focal
/
Transição Epitelial-Mesenquimal
/
Células A549
/
Neoplasias Pulmonares
/
Invasividade Neoplásica
/
Metástase Neoplásica
/
Proteínas de Neoplasias
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Protein & Cell
Ano de publicação:
2020
Tipo de documento:
Artigo
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