Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle cell lymphoma / 医学前沿
Frontiers of Medicine
;
(4): 811-815, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-880944
ABSTRACT
Mantle cell lymphoma (MCL) is a distinct histological type of B-cell lymphoma with a poor prognosis. Several agents, such as proteasome inhibitors, immunomodulatory drugs, and inhibitors of B cell lymphoma-2 and Bruton's tyrosine kinase have shown efficacy for relapsed or refractory (r/r) MCL but often have short-term responses. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin's lymphoma. However, long-term safety and tolerability associated with CAR T-cell therapy are not defined well, especially in MCL. In this report, we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy. CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient. This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL, who are generally elderly and have comorbid conditions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imunoterapia Adotiva
/
Linfoma de Célula do Manto
/
Terapia Baseada em Transplante de Células e Tecidos
/
Receptores de Antígenos Quiméricos
/
Recidiva Local de Neoplasia
Limite:
Adulto
/
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Frontiers of Medicine
Ano de publicação:
2020
Tipo de documento:
Artigo
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