Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice / 中西医结合学报

ABSTRACT

OBJECTIVE@#To understand the protective effects of Ganoderma terpenoid extract (GTE) against Plasmodium berghei-malarial infection in mice, the present study was carried out to evaluate the effects of GTE in combination with chloroquine disulphate (CQ) on erythrocyte-selected inflammatory markers and antioxidant defense status in P. berghei-infected mice.@*METHODS@#P. berghei-infected mice were divided into six groups infected control (IC) group, administered 1 mL Tween 20; GTE@*RESULTS@#Infected mice treated with a combination of GTE and CQ (GT@*CONCLUSION@#Data generated in this study showed that GTE enhanced the anti-plasmodial action of CQ in mice through its anti-inflammatory and antioxidant activities.