Report of 3 cases of acute colchicine poisoning / 中国职业医学

ABSTRACT

OBJECTIVE: To analyze the clinical features, diagnosis and treatment of acute poisoning caused by colchicine. METHODS: The clinical data of 3 cases of acute colchicine poisoning were retrospectively analyzed. RESULTS: All the 3 cases had a clear history of colchicine overdose, at the doses of 30.0, 50.0 and 58.5 mg. These 3 cases had different degree of gastrointestinal symptoms, bone marrow restrain, rhabdomyolysis, myocardial damage and liver damage. After treatment, case 1 and case 2 were discharged. Case 3 had a long history of oral intake of colchicine. Severe metabolic acidosis and abnormal coagulation function occurred in the early stage, and the condition was dangerous. Despite active rescue treatments including blood purification, glucocorticoid, coagulation factors, liver pretection, heart protection and water electrolyte correction, death could not be prevented after taking colchicine 89 hours later.CONCLUSION: There is no specific antidote for colchicine poisoning. The prognosis is poor if there is severe metabolic acidosis and abnormal blood coagulation in early stage.