Clinical analysis on 325 cases of trimethyl tin chloride-induced acute toxic encephalopathy / 中国职业医学

ABSTRACT

OBJECTIVE: To investigate the clinical characteristics of acute toxic encephalopathy caused by trimethyltin chloride(TMT). METHODS: Literatures related to TMT acute poisoning accidents occurred in China from 1998 to 2018 were collected and analyzed using the CNKI, WEIPU Database and WANFANG Database. The clinical manifestations, neuroimaging images, electroencephalography(EEG), treatment and other data were collected and analyzed. RESULTS: A total of 15 literatures were included in the study. These studies involved 15 incidents with 1 339 patients with TMT acute poisoning. Among them, 325 patients(24.3%) presented toxic encephalopathy. They were moderate to severe poisoning.The clinical manifestations were headache, dizziness, limb weakness, abnormal mental behavior and memory loss. Magnetic resonance imaging(MRI) and computed tomography(CT) were performed in 105 and 86 patients, respectively, with 29.5% and 26.7% of abnormal rate. There was no significant difference in the abnormal rate between the above two methods(P>0.05). 294 cases were examined by electroencephalogram. The abnormal rate was 93.9%, which was higher than that of the MRI and CT examination(P<0.05). Patients with toxic encephalopathy were treated with glucocorticoid. Some patients were treated with hyperbaric oxygen, nerve cell nutritional drugs and rehabilitation exercise after the conditions were stable. CONCLUSION: The patients with TMT toxic encephalopathy were moderately and severely poisoned by TMT. EEG examination is helpful for the diagnosis and treatment of TMT toxic encephalopathy.