Meta-analysis on the effects of bronchoalveolar lavage on arterial blood gas and respiratory function in pneumoconiosis patients / 中国职业医学

ABSTRACT

OBJECTIVE: To analyze the effect of bronchoalveolar lavage( BAL) on respiratory function and arterial blood gas of pneumoconiosis patients. METHODS: The published literatures about relationship between BAL and respiratory function and arterial blood gas in pneumoconiosis patients from China National Knowledge Internet,Wanfang Database,Chinese Biomedical Literature Database,Chinese Journal Database,Pub Med,Embase,Web of Science Database and the Cochrane Library Database and so on from 2000 to 2016 were retrieved,collected,and screened by using bibliometric method. The data was analyzed by Meta analysis with the help of Rev Man 5. 0 software. The weighted mean difference( MD) and 95%confidence interval( CI) were calculated on selected literatures. RESULTS: A total of 20 articles were selected and used.The forced vital capacity( FVC)( MD = 0. 21,95% CI 0. 04-0. 37),the forced expiratory volume in one second( FEV1)( MD = 0. 12,95% CI 0. 01-0. 23),the maximum ventilatory volume( MD = 10. 73,95% CI 3. 48-17. 98) and partial pressure of oxygen( MD = 8. 85,95% CI 0. 30-17. 39) in the patients after BAL were higher than before( P < 0. 05),while the partial pressure of carbon dioxide in artery( MD =-3. 58,95% CI-5. 61--1. 55) decreased( P < 0. 01).Both of the FEV1/FVC( MD = 2. 08,95% CI-6. 27-10. 43) and the FEV1%( MD = 0. 86,95% CI-0. 55-2. 28)had not statistically significance before and after BAL( P > 0. 05). CONCLUSION: BAL can improved respiratory function and arterial blood gas in pneumoconiosis patients.