Regulation of non-immunomodulatory interaction between pertussis toxin and host cells / 国际儿科学杂志

ABSTRACT

Pertussis toxin(PTx), an important toxin that produced by Bordetella pertussis, is an important pathogenic factor in the pathogenesis of whooping cough.The previous studies have showed that PTx interacting proteins vary distinctly in size, ranging from the 43 kD surface protein of human lymphocyte to the 200 kD surface protein of insulin secreting cells.PTx has been shown to interact with N-linked oligosaccharides on the surface of host cells, sialoglycoprotein-like factors, glycoproteins such as haptoglobin, fetuin, G D1a glycolipids.Especially, the interaction of PTx with its receptor Gi protein can result in increased intracellular cAMP level, which will lead to multiple physiological responses.However, the current limited understanding of other PTx modified substrates and interacting proteins in cells has seriously hindered our understanding on the mechanism that PTx regulates other signaling pathways and physiological functions of the host.