Research status and prospect of SPOP in renal cell carcinoma / 国际外科学杂志

ABSTRACT

Renal cell carcinoma is one of the most common urinary tract cancers, accounting for 90% of renal cancer cases, and the clear cell renal cell carcinoma is its most common subtype. Because of poor response to conventional anti-cancer treatment, metastasis may occur in the early stage of renal cell carcinoma. The high degree of metastasis of renal cell carcinoma determines the necessity and importance of early diagnosis. Although a lot of researches about renal cell carcinoma have been carried out, its underlying mechanisms still remain unclear. Recent studies have shown that spot-type POZ protein (SPOP) can perform biological functions in a cancer type-specific way. Based on the latest findings, this article reviewed the current research status and prospectives of SPOP in renal cancer cells.