The relationship between platelet volume-related indices for the prognosis of acute ischemic stroke with intravenous thromblysis / 中华急诊医学杂志

ABSTRACT

Objective:To investigate the prognostic value of platelet volume indices (PVIs), neutrophil/lymphocyte ratio (NLR) and the combination of these parameters for the neurological function of acute ischemic stroke (AIS) patients after intravenous thrombolysis.Methods:From January 2016 to January 2019, the data of 147 AIS patients with intravenous thrombolysis in the Emergency Department of Peking University People's Hospital who met the diagnostic criteria of AIS were retrospectively analyzed. The patients were divided into two groups according to modified rank in scale (MRS) score MRS≤2 and MRS≥3. The general information, past medical history and laboratory examination results of each group were compared. Logistic regression analysis was used to analyze the risk factors of poor prognosis of neurological function in AIS patients with thrombolysis.Results:NLR ( OR=1.045, 95% CI 1.032-2.350, P=0.032), mean platelet volume (MPV) ( OR=4.212, 95% CI1.074-16.513, P=0.039), MPV×NLR/PLT ( OR=5.711, 95% CI 1.342-24.298, P=0.018), platelet distribution width (PDW) ( OR=1.015, 95% CI 1.001-2.372, P=0.032), and NIHSS score ( OR=1.266, 95% CI 1.111-1.443, P<0.01) were related with poor prognosis neurological function of AIS patients with intravenous thrombolysis. Conclusions:MPV, NLR, MPV×NLR/PLT PDW and NIHSS scores are the risk factors for poor prognosis of neurological function in AIS patients with thrombolysis. MPV×NLR/PLT can predict the neurological severity of AIS after 3 months.