Prevention of gestational diabetes mellitus in overweight or obese women / 中华围产医学杂志

ABSTRACT

Overweight or obese women have a significantly increased risk of gestational diabetes mellitus (GDM). With the increasing prevalence of obesity among women of reproductive age, the prevalence of GDM has also risen. The prevention of GDM during pregnancy is particularly important in reducing the adverse pregnancy outcomes for both mothers and their offspring and decreasing the economic burden of the society. Lifestyle interventions (exercises, dietary), dietary supplementation, and pharmacological approaches are the main preventive measures. Exercise intervention and myo-inositol supplementation are effective in preventing GDM; dietary intervention and combined lifestyle intervention have some benefits, but the results remain controversial; probiotic supplementation and prophylactic use of metformin seem to be ineffective; the effectiveness of vitamin D supplementation is unclear.