Progress of sonodynamic therapy in treatment of tumors / 肿瘤研究与临床

ABSTRACT

Ultrasound, as a mechanical wave with frequencies > 20 kHz, needs an elastic medium to transmit energy, and it can safely penetrate into the tissues without significant attenuation. Sonodynamic therapy is a new noninvasive therapy based on ultrasound, and it mainly uses low-intensity ultrasound to activate sonosensitizers to produce cytotoxic reactive oxygen species to kill cells. Compared with photodynamic therapy, sonodynamic therapy overcomes the limitation of low penetration depth of light for deep tumors. In addition, sonodynamic therapy can be combined with photothermal therapy, chemotherapy, immunotherapy and gas therapy for synergistic therapy of tumors. This review aims to discuss the latest development of sonodynamic therapy in the field of tumor treatment.