Analysis of related risk factors of pulmonary hypertension in patients with COPD in high altitude area / 公共卫生与预防医学

ABSTRACT

Objective To investigate the characteristics and risk factors of pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD) in plateau areas. Methods To select 562 COPD patients in Qinghai Plateau from January 2017 to December 2020 in the Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital. The patients were divided according to pulmonary artery systolic pressure (PASP) pulmonary hypertension (PH) group (PASP≥40mmHg) and non-pulmonary hypertension (NPH) group (PASP2=30.848, P＜0.001). The percentage of forced expiratory volume in one second (FEV1%), blood oxygen saturation, B-type natriuretic peptide, mean platelet volume (MPV) in the PH group were different from those of NPH group (P<0.05). Multivariate logistic regression analysis showed that FEV1% [OR=1.082 (95%CI 1.038-1.256)], MPV [OR=1.696 (95%CI 1.273-2.257)] were risk factors for COPD patients with PH in high altitude areas (P<0.05). Conclusion The incidence of PH is higher in COPD patients in plateau areas, and COPD patients with lower FEV1% and higher MPV are more likely to develop PH.