Acetylcholinesterase Inhibitors from Angelica polymorpha Stem
Natural Product Sciences
;
: 97-102, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-88723
ABSTRACT
Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (−)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (−)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4 - 6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with IC₅₀ values ranging from 1.4 to 37.5 µM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acetilcolinesterase
/
Escopoletina
/
Inibidores da Colinesterase
/
Cromonas
/
Cumarínicos
/
Angelica
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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