Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 445-451, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-887878
ABSTRACT
Breast cancer patients with bone,liver and lung metastases tend to have a poor prognosis.According to Paget's "seed and soil" theory,metastatic cancer cell "seeds" must fall on congenial target organ "soil".Studies have shown that myeloid-derived suppressor cells(MDSCs)can be recruited at the site of breast cancer metastasis in advance and play a role in the metastasis of breast cancer cells.This paper reviews the biological characteristics of MDSCs,the roles of MDSCs in peripheral circulation,prometastatic niche,and metastatic site during breast cancer metastasis,as well as the research progress of MDSCs-targeted treatment of breast cancer metastasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Mama
/
Microambiente Tumoral
/
Células Supressoras Mieloides
/
Neoplasias Pulmonares
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2021
Tipo de documento:
Artigo
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