Research Progress of Pharmacological Intervention of Sevoflurane-induced Nerve Injury in the Developing Brain / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 462-468, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-887880
ABSTRACT
Sevoflurane is one of the most commonly used inhaled anesthetics in obstetric and pediatric general anesthesia.According to related literature,this article reviews major possible mechanisms including myelin formation damage,nerve inflammation,cell apoptosis,oxidative stress,inhibition of histone acetylation,synapsis and receptor changes of sevoflurane-induced neurotoxicity in animal experiments.Furthermore,we summarize the neuroprotection effects and functioning mechanisms of anti-anemia medicine,plant-based drugs,alpha 2 adrenoceptor agonists and others,aiming to provide a basis for the brain protection of fetuses and infants during the perioperative period.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Apoptose
/
Estresse Oxidativo
/
Fármacos Neuroprotetores
/
Anestésicos Inalatórios
/
Sevoflurano
/
Éteres Metílicos
Limite:
Animais
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2021
Tipo de documento:
Artigo
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