Progress of parathyroid hormone regulating bone metabolism via different signaling pathways / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 584-588, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-888319
ABSTRACT
Parathyroid hormone is one kind of osteoanabolic agents widely used in clinic for osteoporosis. However, parathyroid hormone needs to be further optimized in the treatment of osteoporosis due to its two way regulatory effect of bone formation with low-dose intermittent treatmentand bone resorption with high-dosecontinuous treatment. Hence, based on the molecular mechanism of parathyroid hormone regulating bone metabolism, we conclude that parathyroid hormone regulates bone metabolism mainly through the following signaling pathways (1) Gs/cAMP/PKA signaling pathway, whichis the main mechanism of parathyroid hormone regulating bone metabolism to lead to bone formation or bone resorption. (2) G
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Osteoporose
/
Hormônio Paratireóideo
/
Reabsorção Óssea
/
Transdução de Sinais
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2021
Tipo de documento:
Artigo
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