Paradoxical effects of arsenic in the lungs
Environmental Health and Preventive Medicine
;
: 80-80, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-888614
ABSTRACT
High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of previous studies, we infer that low- and medium-concentration arsenic cause lung diseases in a dose-dependent manner. Arsenic trioxide (ATO) is recognized as a chemotherapeutic drug for acute promyelocytic leukemia (APL), also having a significant effect on lung cancer. The anti-lung cancer mechanisms of ATO include inhibition of proliferation, promotion of apoptosis, anti-angiogenesis, and inhibition of tumor metastasis. In this review, we summarized the role of arsenic in lung disease from both pathogenic and therapeutic perspectives. Understanding the paradoxical effects of arsenic in the lungs may provide some ideas for further research on the occurrence and treatment of lung diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arsênio
/
Relação Dose-Resposta a Droga
/
Pulmão
/
Neoplasias Pulmonares
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Environmental Health and Preventive Medicine
Ano de publicação:
2021
Tipo de documento:
Artigo
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