Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

ABSTRACT

The aim of this work is to discover the inhibitory mechanism of tea peptides and to analyse the affinities between the peptides and the angiotensin-converting enzyme (ACE) as well as the stability of the complexes using in vitro and in silico methods. Four peptide sequences identified from tea, namely peptides I, II, III, and IV, were used to examine ACE inhibition and kinetics. The half maximal inhibitory concentration (IC