Clinical Significance of Serum Interleukin-18 Concentration in the Patients with Atopic Dermatitis / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 128-132, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-88869
ABSTRACT
BACKGROUND:
Interleukin (IL)-18, a potent inducer of interferon gamma (IFN-gamma), is known to have a role in diseases involving type-2 T helper cell responses including atopic dermatitis. In this study, we aimed to determine the clinical significance of serum IL-18 level in the patients with atopic dermatitis.METHODS:
Serum concentration of IL-18, IFN-gamma, IgE, and blood eosinophil were measured in the patients with atopic dermatitis and healthy control subjects, and their association with the clinical score of the disease was analysed.RESULTS:
Serum concentrations of IL-18 were significantly elevated in patients with atopic dermatitis compared to the healthy controls (332 pg/mL vs 151 pg/mL, P<0.05). Serum levels of IL-18 (r=0.41, P=0.001), eosinophil (r=0.36, P=0.003), and IgE (r=0.32, P=0.009) correlated with clinical scores in the patients. Also, multiple regression analysis indicated that serum IL-18 and IgE levels were independent predictors for the clinical score of atopic dermatitis (r2=0.25, beta=0.39, P=0.001 and beta=0.32, P=0.009).CONCLUSIONS:
Our results confirmed a significant correlation between the concentration of serum IL-18 and the severity of atopic dermatitis. Although serum IL-18 concentration reflects the disease severity, its usefulness as a clinical test needs to be further investigated, because its additive benefit over those of conventional blood tests is not evident so far.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Índice de Gravidade de Doença
/
Imunoglobulina E
/
Curva ROC
/
Interleucina-18
/
Dermatite Atópica
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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