Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study / 医学前沿
Frontiers of Medicine
; (4): 438-447, 2021.
Article
em En
| WPRIM
| ID: wpr-888752
Biblioteca responsável:
WPRO
ABSTRACT
Thoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD remains unknown. Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population (N = 637). After population structure and genetic relationship and ancestry analyses, we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD. We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Estudos de Casos e Controles
/
Análise por Conglomerados
/
Estudos de Coortes
/
Biologia Computacional
/
Predisposição Genética para Doença
/
Colágeno Tipo III
/
Dissecção Aórtica
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2021
Tipo de documento:
Article