Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5
Acta Pharmaceutica Sinica B
;
(6): 2709-2718, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-888882
ABSTRACT
Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthesis of bisubstrate analogues for PRMTs that incorporate a
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica B
Ano de publicação:
2021
Tipo de documento:
Artigo
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