Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
Acta Pharmaceutica Sinica B
; (6): 2738-2748, 2021.
Article
em En
| WPRIM
| ID: wpr-888885
Biblioteca responsável:
WPRO
ABSTRACT
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical practice. Increasing evidence suggests that CDKs, constituting a kinase family predominantly involved in cell cycle control, are synthetic lethal factors when combined with certain oncogenes, such as
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WPRIM
Idioma:
En
Revista:
Acta Pharmaceutica Sinica B
Ano de publicação:
2021
Tipo de documento:
Article