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Blockade of Nitric Oxide Synthesis Further Diminishes Aquaporin Water Channels in Rat Kidney Subjected to Ischemia/reperfusion Injury / 대한신장학회잡지
Korean Journal of Nephrology ; : 7-12, 2006.
Artigo em Inglês | WPRIM | ID: wpr-89289
ABSTRACT
BACKGOUND The present study examined whether a blockade of nitric oxide (NO) synthesis affects the regulation of aquaporin (AQP) water channels in rats subjected to renal ischemia/reperfusion (I/R).

METHODS:

Renal I/R was experimentally induced by clamping the left renal artery for 60 minutes in rats. The rats were kept for 7 days thereafter, during which they were supplied with tap water containing NG-nitro-L-arginine methyl ester (L-NAME, 100 mg/L). The expression of AQP1-3 was determined in the kidney by Western blot analysis.

RESULTS:

In renal I/R injury, the expression of AQP2 was significantly decreased. The treatment with L-NAME further diminished the expression of AQP2. Although the expression of either AQP1 or AQP3 was not significantly altered in the kidney subjected to I/R, it was also significantly decreased by the treatment with L-NAME.

CONCLUSION:

It is suggested that endogenous NO system should play a role in the regulation of AQP water channels in rat kidney subjected to I/R injury.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artéria Renal / Reperfusão / Western Blotting / Constrição / NG-Nitroarginina Metil Éster / Aquaporinas / Isquemia / Rim / Óxido Nítrico Limite: Animais Idioma: Inglês Revista: Korean Journal of Nephrology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artéria Renal / Reperfusão / Western Blotting / Constrição / NG-Nitroarginina Metil Éster / Aquaporinas / Isquemia / Rim / Óxido Nítrico Limite: Animais Idioma: Inglês Revista: Korean Journal of Nephrology Ano de publicação: 2006 Tipo de documento: Artigo