Increased Serum Thymus and Activation-regulated Chemokine (TARC) Levels in Children with Atopic Dermatitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 250-256, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-8940
ABSTRACT
PURPOSE:
Thymus and activation-regulated chemokine (TARC) is responsible for the trafficking of Th2 lymphocytes into sites of allergic inflammation. We tested whether TARC is a useful marker for childhood atopic dermatitis (AD) and we evaluated age-related differences in the level of TARC.METHODS:
Serum TARC level, serum total IgE level, total eosinophil count and specific IgE level were measured in 401 children. They were characterized as having IgE-mediated atopic dermatitis (n=157), non-IgE mediated atopic dermatitis (n=107), or as healthy control subjects (n=137).RESULTS:
TARC levels in AD significantly were higher than those in healthy control subjects. (152.9+/-11.6 vs 56.7+/-5.2 pg/mL, P< 0.05) Serum TARC levels significantly correlated with disease severity (SCORAD index) both in children with IgE mediated AD (r=0.670, P< 0.05) and children with non-IgE mediated AD. (r=0.605, P< 0.05) Serum TARC levels in control subjects decreased in accordance with age. (r=-0.201, P< 0.05)CONCLUSION:
Serum TARC might be a useful marker for disease severity both in children with IgE mediated AD and children with non-IgE mediated AD. Serum TARC levels in control subjects decreased in accordance with ages.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Timo
/
Imunoglobulina E
/
Linfócitos
/
Dermatite Atópica
/
Eosinófilos
/
Quimiocina CCL17
/
Inflamação
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Pediatric Allergy and Respiratory Disease
Ano de publicação:
2005
Tipo de documento:
Artigo
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