Ozone Chemonucleolysis on the Lumbar Intervertebral Disc of the Rabbit
Journal of Korean Neurosurgical Society
; : 570-574, 2003.
Article
em Ko
| WPRIM
| ID: wpr-89769
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: This study is aimed to evaluate the chemonucleolytic effect of medical ozone by investigating the change of the signal intensity on magnetic resonance imaging (MRI) scan after injection of medical ozone into the lumbar intervertebral disc of the rabbit. METHODS: A series of 21 intradiscal injections of 1ml of medical ozone(30microgram of ozone per ml of oxygen) was performed in 7 young adult rabbits. Two control series, which 20 intradiscal injections of 0.1ml of iodine contrast medium in 7 young adult rabbits and 21 intradiscal injections of 0.05ml of chymopapain in 7 young adult rabbits, were performed. T2 weighted MRI scan was performed pre-operatively and at 4 weeks after injection. RESULTS: T2-weighted MRI scan of intervertebral disc spaces demonstrated significantly decreased signal intensities in the series (n=21) of intradiscal injections of medical ozone at 4 weeks after injection, as compared with the control series of intradiscal injections of 0.1ml of iodine contrast medium. T2-weighted MRI scan of intervertebral disc spaces demonstrated significantly decreased signal intensities in the series(n=21) of intradiscal injections of chymopapain at 4 weeks after injection. Any neurologic deficit or complication was not found in all groups. CONCLUSION: Intradiscal injections of medical ozone into the lumbar intervertebral disc of the rabbits are proven to have chemonucleolytic effects.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Ozônio
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Quimiólise do Disco Intervertebral
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Imageamento por Ressonância Magnética
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Quimopapaína
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Disco Intervertebral
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Iodo
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Manifestações Neurológicas
Limite:
Animals
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Humans
Idioma:
Ko
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2003
Tipo de documento:
Article