Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro
Experimental & Molecular Medicine
;
: 133-137, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-90138
ABSTRACT
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenantrenos
/
Medicamentos de Ervas Chinesas
/
Movimento Celular
/
Células Cultivadas
/
Fator 2 de Crescimento de Fibroblastos
/
Raízes de Plantas
/
Neovascularização Fisiológica
/
Inibidores da Angiogênese
/
Salvia miltiorrhiza
/
Células Endoteliais
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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