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Calcium signal-mediated activation of NLRP3 inflammasome / 中国药科大学学报
Journal of China Pharmaceutical University ; (6): 513-521, 2021.
Artigo em Chinês | WPRIM | ID: wpr-904321
ABSTRACT
@#Nod-like receptor protein 3 (NLRP3) inflammasome, which is an important component of the innate immune system, can recognize a variety of pathogens and cell damage, induce the secretion of IL-1β and IL-18, and regulate imflammatory response.More and more studies in recent years have shown that Ca2+ signaling plays an important role in NLRP3 inflammasome activation induced by various NLRP3 inflammasome agonists, and is closely related to the occurrence of related diseases.The article reviews the literatures on Ca2+ and NLRP3 inflammasome, focusing on the potential role of Ca2+ signaling in the activation and regulation of NLRP3 inflammasome, to provide new ideas for the treatment of illness caused by NLRP3 inflammasome.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of China Pharmaceutical University Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of China Pharmaceutical University Ano de publicação: 2021 Tipo de documento: Artigo