Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
Experimental & Molecular Medicine
;
: 222-229, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-90610
ABSTRACT
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of t-RVT has not yet been reported. In this study, we show that t-RVT increases glucose uptake in C2C12 myotubes by activating AMP-activated protein kinase (AMPK), uncovering an antidiabetic potential of t-RVT for the first time. AMPK plays a central role in the regulation of glucose and lipid metabolism, and hence it is considered a novel therapeutic target for metabolic syndrome such as type 2 diabetes. t-RVT significantly induced glucose uptake in C2C12 cells, via AMPK activation, but not a phosphatidylinositol-3 kinase (PI-3 kinase) signal pathway. The induced glucose uptake was attenuated by pretreatment with a pharmacological inhibitor for AMPK, indicating that the effect of t-RVT primarily depends on AMPK activation. However, in the presence of insulin, t-RVT also potentiated the effect of insulin on glucose uptake via AMPK activation, which led to further activation of PI-3 kinase/Akt signal pathway.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estilbenos
/
Transporte Biológico
/
Linhagem Celular
/
Proteínas Serina-Treonina Quinases
/
Fibras Musculares Esqueléticas
/
Ativação Enzimática
/
Proteínas Proto-Oncogênicas c-akt
/
Proteínas Quinases Ativadas por AMP
/
Fosfatidilinositol 3-Quinase
/
Glucose
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2007
Tipo de documento:
Artigo
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