Regulatory mechanisms of microRNAs involved in pubertal development / 国际儿科学杂志

ABSTRACT

The regulatory mechanisms of pubertal development are complex and affected by many factors.MicroRNAs, which major participants in epigenetics, are short single-stranded RNAs composed of 21-25 nucleotides.They can regulate the expression or translation of multiple target genes, playing an important role in complex biological phenomena.During pubertal development, microRNAs can regulate the expression of related genes on the hypothalamic-pituitary-gonadal axis(HPGA). Recently, studies have found that the lack or overexpression of some specific microRNAs can cause abnormal pubertal development(premature or delayed)and lead to reproductive disorders, providing a new direction for the diagnosis and treatment of puberty diseases.Here we mainly review the regulatory mechanisms that microRNAs participate in pubertal development.