Mechanism study of Taraxaci Herba in the treatment of breast cancer based on network pharmacology / 国际中医中药杂志

ABSTRACT

Objective:To explore the mechanism of Taraxaci Herba in the treatment of breast cancer by screening out the active ingredients and targets, so as to construct a herb-ingredient-disease-target network based on network pharmacology. Methods:Based on Batman TCM, PubChem, SwissTargePrediction database and GeneCards and OMIM database to screen out active ingredients and corresponding targets of Taraxaci Herba by using Cytoscape software to construct the interactive network among medicine and disease to screen out the potential ingredients and targets of Taraxaci Herba in the treatment of breast cancer. Finally, the information of signaling pathway was obtained after the GO enrichment analysis and KEGG pathway analysis were performed based on R softwares, and to explore the mechanism of action. Results:Expect to get 8 active ingredients, and 42 targets gene. And futher predict that the mechanism may relate to MicroRNAs in cancer signaling pathway, mTOR signaling pathway, Prolactin signaling pathway and RNA polymerase Ⅱ proximal promoter sequence-specific DNA signaling pathway. Among the pathways, Akt1, PTGS2, ESR1, NFKB1 and AR genes may play a crucial role.Conclusion:The effect of Taraxaci Herba on breast cancer is multi-component, multi-target and multi-channel, which provides a basis for further understanding the mechanism and further research of dandelion in treating breast cancer.