Evidence-based treatment of chronic heart failure in children / 中华实用儿科临床杂志

ABSTRACT

Heart failure (HF) is a common critical illness in pediatrics.At present, the evidence-based medicine for the treatment of chronic HF in children is significantly less than that in adults.There is a lack of relevant evidence on the effectiveness and safety of anti-HF drugs and technologies in children.Due to the fact that the treatment theory and experience are largely based on the research data about adults, and the domestic and foreign consensus or guidelines for the treatment of pediatric chronic HF are out of date, pediatric cardiologists are facing huge challenges.In recent years, the novel drugs and technologies in children have been adopted gradually, for instance, angiotensin receptor-neprilysin inhibitors and Ivabradine have attracted rising attention in the treatment of pediatric HF; Such technologies as cardiac resynchronization and radiofrequency ablation can significantly improve the prognosis of some kinds of chronic HF; the advancement of ventricular assist device provides the possibility for its wide application.Based on the current situation, the safety and efficacy of both traditional anti-HF drugs and new drugs and technologies shall be verified in future by multi-center, large-sample and high-quality clinical research, so as to provide a basis for the treatment strategy of chronic HF in children.