Research progress on AMPK/mTOR signaling pathway involved in immunometabolic regulation in sepsis / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 810-813, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-908378
ABSTRACT
The occurrence, development and prognosis of sepsis are closely related to immune regulation.Immunometabolism has been the research hotspot of immune intervention in sepsis in recent years.AMP-activated protein kinase(AMPK)and mammalian target of rapamycin(mTOR)are star molecules involved in metabolic regulation.As an important way of immunometabolic regulation in sepsis, AMPK-mTOR is involved in the process of chemotaxis of neutrophils, the polarization of macrophages, the development and differentiation of natural killer cells and dendritic cells, and the development and functional regulation of T cells.This article reviewed the research progress of AMPK-mTOR signaling pathway on regulating metabolic reprogramming in immune cells, which contributes to immunoregulation in sepsis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pediatric Emergency Medicine
Ano de publicação:
2021
Tipo de documento:
Artigo
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