The analysis of clinical indexes in patients with nonalcoholic fatty liver disease combined with hypertension / 中国医师进修杂志

ABSTRACT

Objective:Non-alcoholic fatty liver disease (NAFLD) is not only a liver manifestation of metabolic syndrome, but also related to type 2 diabetes, dyslipidemia and hypertension closely. This study aims to explore the correlation between clinical and experimental indexes and disease occurrence in patients with NAFLD combined with essential hypertension.Methods:One hundred and thirty-four patients with NAFLD combined with essential hypertension and 98 patients in the control group were enrolled in this study from March 2019 to March 2021 in Dalian Central Hospital. The clinical baseline and test indexes of the two groups were compared and analyzed, and the logistic regression analysis was also performed.Results:The mean and median values of alanine aminotransferase, γ-glutamyl transpeptidase, lactate dehydrogenase and triacylglycerol in the experimental group were higher than those in the control group 22 U/L vs. 17 U/L, 23 U/L vs. 17 U/L, 179 U/L vs. 173 U/L, 1.68 mmol/L vs. 1.45 mmol/L, while the mean and median values of homocysteine, albumin (ALB), creatinine and free triiodothyronine were lower than that in the control group 11.2 μmol/L vs. 12.2 μmol/L, 41.5 g/L vs. 43.5 g/L, 54 μmol/L vs. 60 μmol/L, (4.657 ± 0.599) pmol/L vs. (4.850 ± 0.574) pmol/L ( P<0.05). Multivariate Logistic regression analysis showed that BMI, diabetes and ALB were independently correlated with NAFLD. Conclusions:The BMI and diabetes were independent risk factors for NAFLD in patients with essential hypertension, and ALB is an independent protective factor.