Meta-analysis of effects of laparoscopic sleeve gastrectomy on vitamins and trace elements in obese patients / 中华临床营养杂志

ABSTRACT

Objective:To evaluate the changes in vitamins and trace elements in obese patients after laparoscopic sleeve gastrectomy (LSG).Methods:A systematic retrieval of the available literature was performed using Pubmed, Embase, Cochrane library, Web of Science, WanFang data and CNKI databases and studies were selected per predefined eligibility criteria. Statistical analysis was performed using Stata 13.0.Results:A total of 22 studies with 5320 individuals with obesity who underwent LSG were identified as eligible for inclusion. A significant increase was observed in serum 25(OH)D ( SMD = 0.59, 95% CI 0.16 to 1.03, P = 0.007), phosphorus ( SMD = 0.28, 95% CI 0.09 to 0.47, P = 0.004) and iron ( SMD = 0.46, 95% CI 0.31 to 0.61, P < 0.01) after LSG. A significant decrease in serum zinc ( SMD = -0.41, 95% CI -0.81 to -0.01, P = 0.044) was observed after LSG. But no significant changes in serum calcium ( SMD = 0.11, 95% CI -0.14 to 0.36, P = 0.385), folate ( SMD = 0.27, 95% CI -0.08 to 0.62, P = 0.133), vitamin B 12 ( SMD = 0.11, 95% CI -0.25 to 0.47, P = 0.563) and magnesium ( SMD = 0.53, 95% CI -0.08 to 1.14, P = 0.09) were observed. Conclusions:The changes of serum nutritional measurements in individuals with obesity who underwent LSG are uncertain. Therefore, it is recommended to monitor the nutritional laboratory values and add supplements when necessary to prevent postoperative malnutrition.