Molecular markers for immunological evaluation and monitoring of patients with idiopathic pulmonary fibrosis / 中国医师杂志

ABSTRACT

Idiopathic pulmonary fibrosis (IPF) is a common pulmonary interstitial disease with unknown etiology. Its pathogenesis is unknown and there is no specific drug. Its progress is urgent and its prognosis is heterogeneous. Many studies have found that abnormal immune system function of the body and lungs may be related to the pathogenesis, progression and prognosis of IPF. Combined with the literature, this paper comprehensively analyzes the distribution of IPF related immune cells, cytokines and immunoglobulins in peripheral blood and bronchoalveolar lavage fluid of IPF patients, and discusses the research potential and clinical application potential value of these cells and molecular markers as immune evaluation and monitoring for IPF diagnosis, condition evaluation and prognosis prediction.