A Comparative Study of Central Hemodynamics in Parkinson's Disease
Journal of Movement Disorders
;
: 135-139, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-90984
ABSTRACT
OBJECTIVE:
To explore the central aortic pressure in patients with Parkinson's disease (PD).METHODS:
We investigated central arterial stiffness by measurement of the augmentation index (AIx) in PD patients. Patients were eligible for the study if they were de novo PD and 45 years of age or older. The patients’ demographics, vascular risk factors, and neurologic examinations were collected at baseline. The AIx was measured by applanation tonometry.RESULTS:
A total of 147 subjects (77 in control and 70 in PD groups) were enrolled in the study. While there was no significant difference in peripheral systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure between groups, peripheral pulse pressure (PP) was significantly lower in the PD group than in the control group (p = 0.012). Regarding central pressure, aortic DBP was significantly higher and PP was significantly lower in the PD group (p = 0.001, < 0.0001). Although there was no significant difference in the AIx between the groups, a trend toward a lower AIx was observed in the PD group (31.2% vs. 28.1%, p = 0.074).CONCLUSION:
This study showed that peripheral and central PP was significantly lower in the PD group than in the control group. Our study suggests that PD patients may have a low risk of a cardiovascular event by reason of a lower PP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Pressão Sanguínea
/
Demografia
/
Fatores de Risco
/
Rigidez Vascular
/
Pressão Arterial
/
Hemodinâmica
/
Manometria
/
Exame Neurológico
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Movement Disorders
Ano de publicação:
2017
Tipo de documento:
Artigo
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