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Research progress in role and mechanism of damage-associated molecular patterns in lung injury after acute spinal cord injury / 中华创伤杂志
Chinese Journal of Trauma ; (12): 756-760, 2021.
Artigo em Chinês | WPRIM | ID: wpr-909934
ABSTRACT
Acute spinal cord injury(ASCI),commonly seen in spinal surgery,is usually caused by mechanical injury to the spine. ASCI can lead to secondary lung injury and even acute respiratory distress syndrome(ARDS),seriously endangering the life safety of patients. Damage-associated molecular pattern(DAMP)is a sort of endogenous substances released after injury,including intracellular proteinsextracellular matrix,secretory factors and nucleic acid-related products. DAMP released after ASCI activates downstream signaling pathways and participates in lung injuries. DAMP-related studies have revealed molecular mechanism of lung injury after ASCI,and explored the possible therapeutic targets of lung injury. In this study,the authors review the mechanism of action of DAMP in lung injury after ASCI and the role of different kinds of DAMP in lung injury,so as to provide new ideas for clinical treatment of lung injury after ASCI.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Trauma Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Trauma Ano de publicação: 2021 Tipo de documento: Artigo