Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy
Journal of Neurogastroenterology and Motility
;
: 274-278, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-91000
ABSTRACT
BACKGROUND/AIMS:
Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD). Recent studies have shown that neuropathy has positive role on the development of GERD in type II DM, although its pathogenesis has not been fully understood yet. The aim of this study was to investigate whether neuropathy really contribute to the development of GERD and typical GERD symptoms in patients with type II DM in Korea.METHODS:
One hundred and nineteen patients with type II DM who had given informed consents were enrolled. All patients underwent electromyography to check the presence of peripheral neuropathy, face-to-face interview to evaluate their typical GERD symptoms and esophagogastroduodenoscopy to look for the presence of erosive esophagitis. Ninety-five patients were finally included for this study and they were divided according to the presence or absence of the peripheral neuropathy.RESULTS:
The mean age of 95 patients was 59.3 +/- 9.1 years and the mean disease duration of DM was 9.3 +/- 5.9 years. Typical GERD symptoms were similarly found in both groups with and without peripheral neuropathy (23.6% vs 22.8%, P = 0.921). Erosive esophagitis was more prevalent in patients with neuropathy than in those without neuropathy (31.5% vs 10.5%, P = 0.022).CONCLUSIONS:
In patients with type II DM, peripheral neuropathy is an independent risk factor for the erosive esophagitis. However, peripheral neuropathy did not contribute to the presence of the typical GERD symptoms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Refluxo Gastroesofágico
/
Prevalência
/
Fatores de Risco
/
Endoscopia do Sistema Digestório
/
Doenças do Sistema Nervoso Periférico
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 2
/
Eletromiografia
/
Esofagite
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Pesquisa qualitativa
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Neurogastroenterology and Motility
Ano de publicação:
2011
Tipo de documento:
Artigo
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