Comparison of Surgical Result between External Dacryocystorhinostomy with Mitomycin-C and without Mitomycin-C

ABSTRACT

PURPOSE: To compare the surgical results of external dacryocystorhinostomy with intraoperative application of mitomycin-C and external dacryocystorhinostomy without application of mitomycin-C. METHODS: In 80 eyes which underwent external dacryocystorhinostomy, group 1 included 40 eyes with intraoperative mitomycin-C, and group 2 (control group) included 40 eyes without mitomycin-C. In group 1, 5 minute application with 0.4 mg/ml mitomycin-C was intraoperatively performed on the osteotom site and the incision site of posterior mucosal flap. Postoperative follow-up was done at 1-week interval for 1 month, at 2-week interval after 2 months and 1-month interval for 3 to 6 months. We determined the surgical success by the irrigation with normal saline and epiphora. By the irrigation with normal saline, no reflux was regarded as the anatomical success, no reflux with no epiphora was regarded as the functional success. We checked the statistical significance with Fisher's Exact Test. RESULTS: After 6 months, anatomical success rate was 95.0% (38/40) in group 1 and 90.0% (36/40) in group 2. It was not statistically significant (p>0.05). And functional success rate was 90.0% (36/40) in group 1 and 85.0% (34/40) in group 2; it had no statistic significance (p> 0.05). CONCLUSIONS: Authors conclude that the intraoperative use of mitomycin-C in repeated dacyo-cystorhinostomy or the poor condition of nasal mucosa is more helpful than the primary use of mitomycin-C in external dacyocystorhinostomy.