A study on genes related to cognitive dysfunction in elderly patients with atrial fibrillation / 中华老年医学杂志
Chinese Journal of Geriatrics
;
(12): 1343-1347, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-911015
ABSTRACT
Objective:
To investigate the molecular genetic mechanisms of cognitive dysfunction in elderly patients with atrial fibrillation.Methods:
A case-control study was conducted to analyze statistical data from a previous epidemiological survey, which used a stratified, random cluster sampling method and covered towns and communities in eastern, southern and northern Xinjiang.A total of 8529 residents aged ≥60 years were investigated, of whom, 301 patients with a history of atrial fibrillation or a definitive diagnosis of atrial fibrillation by electrocardiogram during investigation were selected.The patients with atrial fibrillation were divided into a cognitive impairment group(55 cases)and a normal cognitive group(246 cases)according to the diagnostic criteria of cognitive dysfunction.Genotypes of a GWAS on the main atrial fibrillation-related genes were analyzed for genes associated with atrial fibrillation, aging and cognitive impairment.Results:
Unconditional multivariate Logistic regression analysis showed that mental work and non-solitary living were protective factors against cognitive impairment in the elderly with atrial fibrillation( OR=0.206, 95% CI 0.048-0.873; OR=0.286, 95% CI 0.089-0.922; all P<0.05). Klotho(rs571118)TT and the ApoE ε3/ε4 genotypes were independent risk factors for cognitive impairment in elderly patients with atrial fibrillation( OR=3.922, 95% CI 1.326-11.595; OR=6.843, 95% CI 1.263-37.078; all P< 0.05). The interaction between Klotho(rs571118)and ApoE ε3/ε4 was not associated with cognitive impairment in the elderly with atrial fibrillation( OR=1.552, 95% CI 0.703-3.428; OR=1.897, 95% CI 0.967-3.723; OR=0.496, 95% CI 0.061-4.026; all P>0.05).Conclusions:
Klotho(rs571118)TT and the ApoE ε3/ε4 genotypes may promote cognitive dysfunction in elderly patients with atrial fibrillation.The results may serve as a basis for research on the mechanisms of cognitive dysfunction in elderly patients with atrial fibrillation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Chinês
Revista:
Chinese Journal of Geriatrics
Ano de publicação:
2021
Tipo de documento:
Artigo
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