Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
Korean Journal of Veterinary Research
;
: 47-50, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-91207
ABSTRACT
Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Hidrocortisona
/
Radioimunoensaio
/
Líquido Cefalorraquidiano
/
Desidroepiandrosterona
/
Diagnóstico
/
Epilepsia
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2017
Tipo de documento:
Artigo
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