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The Clinical Significance of Serum and Urine Cytokines in Patients with Acute Uncomplicated Pyelonephritis / 대한비뇨기과학회지
Korean Journal of Urology ; : 33-38, 2009.
Artigo em Coreano | WPRIM | ID: wpr-91415
ABSTRACT

PURPOSE:

In this prospective study, we evaluated the clinical significance of inflammatory cytokines in women with acute uncomplicated pyelonephritis undergoing antimicrobial therapy. MATERIALS AND

METHODS:

We analyzed 26 female patients diagnosed with acute uncomplicated pyelonephritis between September 2007 and March 2008. Body temperature, white blood cell (WBC) counts, serum C-reactive protein (CRP), and serum and urine interleukin (IL)-6 and IL-8 were measured before and 12 hours, 24 hours, and 4 days after the intravenous administration of empirical ciprofloxacin.

RESULTS:

Initial serum CRP levels were correlated with initial serum IL-6 and initial urine IL-8 levels. Twenty-four hours after the start of antibiotic treatment, the CRP level and urine IL-8 level continued to be high, whereas serum IL-6 levels decreased significantly (26.1+/-32.4 vs 9.9+/-23.5pg/dl, p or =15mg/dl, n=12) groups according to initial CRP levels, the serum IL-6 level decreased significantly in both the mild (14.2+/-4.0 vs 4.0+/-1.7pg/dl, p<0.01) and the severe (41.1+/-12.7 vs. 22.7+/-16.4pg/dl, p<0.01) groups within 24 hours, whereas CRP and urine IL-8 levels did not change significantly in either group.

CONCLUSIONS:

Clinically, initial serum IL-6 and urine IL-8 levels were increased according to disease severity. Moreover, the serum IL-6 level decreased rapidly after antibiotic treatment within 24 hours. Serum IL-6 levels are a better indicator of the severity of disease and the therapeutic effect of empirical parenteral antibiotic use in patients with acute uncomplicated pyelonephritis than were either CRP or WBC counts.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pielonefrite / Temperatura Corporal / Proteína C-Reativa / Ciprofloxacina / Estudos Prospectivos / Citocinas / Interleucina-8 / Interleucinas / Interleucina-6 / Administração Intravenosa Tipo de estudo: Estudo observacional Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pielonefrite / Temperatura Corporal / Proteína C-Reativa / Ciprofloxacina / Estudos Prospectivos / Citocinas / Interleucina-8 / Interleucinas / Interleucina-6 / Administração Intravenosa Tipo de estudo: Estudo observacional Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Urology Ano de publicação: 2009 Tipo de documento: Artigo